Key result
Dietary folate intake was positively associated with HDL-C (p=0.007), HDL-2 (p=0.0011), HDL-3 (p=0.0022), and apoA1 (p=0.001) levels.
Why the study?
Do specific dietary intakes affect HDL-C, HDL-2, HDL-3, and apoA1 levels in a carotid artery disease case-control cohort?
Population
1,566 participants from a Seattle-based prevalent carotid artery disease case-control study, mean age 65.3…
Design
Case-control
Authors
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Hypothesis-generating in carotid disease; leaves open whether folate intake causally improves HDL subfractions or outcomes.
Case-Control (n=1,566)
Yes
Do specific dietary intakes affect HDL-C, HDL-2, HDL-3, and apoA1 levels in a carotid artery disease case-control cohort?
p-value: p=0.007
Dietary folate, alcohol, and myristic acid are positively associated with multiple HDL sub-phenotypes, whereas carbohydrates and iron are negatively associated, providing insights into diet-lipid interactions beyond total HDL-C.
Kim et al. (2014) conducted a case-control in Carotid artery disease (n=1,566). Dietary micronutrient intake was evaluated on Adjusted levels of HDL-C, HDL-2, HDL-3, and apoA1 (p=0.007). Dietary folate intake was positively associated with HDL-C (p=0.007), HDL-2 (p=0.0011), HDL-3 (p=0.0022), and apoA1 (p=0.001) levels.
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