Key result
IVL uses acoustic shockwaves to fracture calcium and facilitate stent expansion in severely calcific lesions.
Why the study?
Moderate to severe calcific plaques in coronary and peripheral vascular beds portend lower procedural success rates, increased adverse events, and unfavorable outcomes compared with noncalcific plaques.
Intravascular lithotripsy is a novel technique using acoustic shockwaves to modify severely calcific plaques, facilitating stent expansion in coronary and peripheral interventions.
A significant proportion of lesions treated with transcatheter interventions in the coronary and peripheral vascular beds exhibit moderate to severe calcific plaques known to portend lower procedural success rates, increased peri-procedural adverse events, and unfavorable clinical outcomes compared with noncalcific plaques. Adapted from lithotripsy technology used for treatment of ureterorenal calculi, intravascular lithotripsy (IVL) is a novel technique for the treatment of severely calcific plaque lesions that uses acoustic shockwaves in a balloon-based delivery system. Shockwaves induce calcium fractures, which facilitate stent expansion and luminal gain. In this review, the authors summarize the physics, preclinical and clinical data on IVL use in the coronary and peripheral vasculature, and future directions of IVL in transcatheter cardiovascular therapies.
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Kereiakes et al. (2021) conducted a review in Calcific plaque lesions in coronary and peripheral vasculature. Intravascular lithotripsy (IVL) was evaluated. Intravascular lithotripsy (IVL) uses acoustic shockwaves to induce calcium fractures, facilitating stent expansion and luminal gain for the treatment of severely calcific plaque lesions.
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