Key result
While observational studies strongly support viability testing to guide revascularization in heart failure patients, randomized trials have failed to demonstrate a clear survival benefit.
Why the study?
Does routine viability testing prior to revascularisation improve outcomes in patients with heart failure due to coronary artery disease?
Does routine viability testing prior to revascularisation improve outcomes in patients with heart failure due to coronary artery disease?
Current evidence shows a divergence between observational data supporting viability testing and randomized trials showing no clear benefit, emphasizing the need for individualized patient selection and ongoing trials.
Myocardial revascularisation has the potential to restore ventricular function and improve survival in patients with heart failure due to underlying coronary artery disease. Viability testing is routinely used to identify which patients are likely to benefit, given that revascularisation may entail substantial procedural risk. However, while the concept of viability testing and revascularisation of patients with 'hibernating myocardium' is strongly supported by observational series, randomised studies have failed to demonstrate clear benefit. This divergence in the evidence base is reflected in current European and US guidelines, in which viability testing has a class II recommendation. In this article, we review the current evidence for routine viability testing prior to revascularisation of patients with heart failure, outline its use in clinical practice and discuss ongoing trials in the field.
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Cahill et al. (2018) conducted a review in Heart failure with underlying coronary artery disease (Ischaemic cardiomyopathy). Viability testing to guide myocardial revascularisation vs. Standard of care / Medical therapy was evaluated. While observational studies strongly support viability testing to guide revascularization in heart failure patients, randomized trials have failed to demonstrate a clear survival benefit.
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