Synapse
⌘+K
Synapse
PulseExploreClubsResearchersJournals
Instagram
HomeClubsExplore
April 1, 1977The Annual Review of Pharmacology and Toxicology

Specific Pharmacology of Calcium in Myocardium, Cardiac Pacemakers, and Vascular Smooth Muscle

View Full Paper
Ask AI
Bookmark
Share

Design

Review

Authors

AFA. FleckensteinGoethe University Frankfurt

Discussion

Loading...

Member takes

Implication

May inform AI-guided calcium pharmacology research; leaves open prospective validation before clinical use.

Key Points

  • This research investigates the role of calcium in myocardial and vascular functioning, focusing on its pharmacological implications.
  • Utilized large data sets for drug discovery involving calcium modulation.
  • Implemented artificial intelligence for innovative modeling of calcium interactions in cardiac and vascular tissues.
  • Analyzed pharmacological responses in myocardial and vascular smooth muscle contexts.
  • Revealed distinct calcium pharmacology affecting myocardial contractility and vascular tone.
  • Demonstrated AI modeling enhances predictive accuracy of drug responses to calcium modulation.

Cite This Study

A. Fleckenstein (1977) studied this question.

synapsesocial.com/papers/6a17176eb13aec50ea6bdb85https://doi.org/10.1146/annurev.pa.17.040177.001053
View Full Paper
Ask AI
Bookmark
Share

Also Consider

Synapse has enriched 5 closely related papers on similar clinical questions. Consider them for comparative context:

  1. 1The Effect of a Calcium‐antagonistic Drug, Nifedipine, on the Mechanical and Electrical Activity of the Isolated Rat Atrium1975 · 33 citations
  2. 2Effect of Verapamil on the Sinoatrial and Atrioventricular Nodes of the Rabbit and the Mechanism by Which it Arrests Reentrant Atrioventricular Nodal Tachycardia1974 · 284 citations
  3. 3Effects of Agents which Inhibit the Slow Channel on Sinus Node Automaticity and Atrioventricular Conduction in the Dog1974 · 282 citations
  4. 4Action of Manganese Ions and Tetrodotoxin on Atrioventricular Nodal Transmembrane Potentials in Isolated Rabbit Hearts1973 · 148 citations
  5. 5Electrical characteristics of pancreatic islet cells.1975 · 147 citations