Key result
Genetically determined PTSD linked to ~4% greater type 2 diabetes risk per SD.
Why the study?
PTSD patients have high comorbidity with type 2 diabetes, but whether PTSD influences diabetes risk remains unknown.
Does genetic liability to PTSD increase the risk of type 2 diabetes in individuals of European ancestry?
Observational (n=1,108,538)
Does genetic liability to PTSD increase the risk of type 2 diabetes in individuals of European ancestry?
Mendelian randomization analysis suggests that genetic liability to PTSD is causally associated with a slightly increased risk of type 2 diabetes, supporting the need for metabolic screening in PTSD patients.
Posttraumatic stress disorder (PTSD) patients have a high comorbidity with type 2 diabetes (T2D). Whether PTSD influences the risk of diabetes is still not known. We used GWAS data from European ancestry of PTSD (23,121 cases and 151,447 controls) and T2D (80,154 cases and 853,816 controls) to investigate the bidirectional associations between PTSD and T2D by the Mendelian randomization (MR) analysis. We showed that PTSD was causally associated with higher odds of T2D (OR = 1.04, 95% CI: 1.01-1.06, P = 0.0086), but not vice versa. Our study suggests that PTSD may increase the risk of T2D. PTSD sufferers should be screened for T2D and its precursor known as metabolic syndrome.
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Song et al. (2025) conducted an observational in Posttraumatic stress disorder and type 2 diabetes (n=1,108,538). Genetically determined posttraumatic stress disorder vs. Control was evaluated on Type 2 diabetes (OR 1.04, 95% CI 1.01-1.06, p=0.0086). Genetically determined posttraumatic stress disorder was causally associated with a 4% increase in the odds of developing type 2 diabetes per standard deviation increase in PTSD (OR 1.04).
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