What is the clinical evidence from this study?

Study design: Observational. Population: Opioid addiction (n=734). Intervention: Illicit opioid use. Primary outcome: Prevalence of previous deep vein thrombosis (DVT) (95% CI 11.5-16.6).

What does this research mean for the field?

In patients receiving treatment for opioid addiction, the prevalence of previous deep vein thrombosis is 13.9% and the annual incidence rate is 3.2%, with risk independently increased by rising age, female sex, sex-worker status, and intravenous delivery. Novelty: ClaimNovelty.INCREMENTAL. Consensus alignment: ConsensusAlignment.NEUTRAL.

November 28, 2011British Journal of General PracticeOpen Access

Deep vein thromboses in users of opioid drugs: incidence, prevalence, and risk factors

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Key result

In patients receiving treatment for opioid addiction, the prevalence of previous deep vein thrombosis was 13.9% and the annual incidence rate was 3.2%.

Population

734 patients in treatment for illicit opioid addiction registered to a single specialised primary care…

Design

Cohort

Follow-up

5 years (for incidence estimation)

Authors

CCCharles S. CornfordMiddlesbrough College JMJames MasonCentral and North West London NHS Foundation Trust FIFiona InnsUniversity Hospital of North Tees

Discussion

Member takes

Implication

High DVT burden in opioid addiction treatment warrants vigilance; leaves open optimal screening and prevention strategies.

Study Design

Type

Observational (n=734)

Multicenter

Structured PICO

Population

734 patients in treatment for illicit opioid addiction registered to a single specialised primary care practice in Middlesbrough, England. Mean age 34 years, 73% male, 96% white British.

Outcome

Prevalence of previous DVT and annual incidence rate of DVThard clinical

Users of illicit opioids in primary care have a high prevalence (13.9%) and annual incidence (3.2%) of DVT, with risk factors including intravenous drug use, female sex, and sex-worker status, highlighting the need for clinical vigilance.

Limitations

Retrospective and descriptive epidemiological design limits the ability to attribute causes.
Accuracy of analysis is limited by reliance on retrospectively reviewed data sources linking clinical data with self-reported behaviors.
Difficult to determine precisely whether a pulmonary embolism had occurred due to inconsistent use of ventilation-perfusion scans.
The study would not capture patients who died from massive pulmonary emboli.
Doppler ultrasound may be inaccurate in diagnosing recurrent DVT.
Retrospective design linking clinical data with self-reported behaviors limits robustness
Difficulty in determining precisely whether a pulmonary embolism had occurred
Doppler ultrasound may be inaccurate in diagnosing recurrent DVT

Cite This Study

Cornford et al. (2011) conducted an observational in Opioid addiction (n=734). Illicit opioid use was evaluated on Prevalence of previous deep vein thrombosis (DVT) (95% CI 11.5-16.6). In patients receiving treatment for opioid addiction, the prevalence of previous deep vein thrombosis was 13.9% and the annual incidence rate was 3.2%.

synapsesocial.com/papers/6a171abfb13aec50ea6bdeea https://doi.org/10.3399/bjgp11x613115

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Deep vein thromboses in users of opioid drugs: incidence, prevalence, and risk factors

Discussion

Member takes

Implication

Study Design

Structured PICO

Limitations

Cite This Study

Deep vein thromboses in users of opioid drugs: incidence, prevalence, and risk factors

Discussion

Member takes

Implication

Study Design

Structured PICO

Limitations

Cite This Study

Also Consider

Also Consider