Evolution of CHA2DS2-VASc Score for Predicting Risk of Stroke Development in Patients with Atrial Fibrillation

Atrial fibrillation (AF) is associated with dramatic increasing of stroke risk. Development of this serious complication is accompanied by high mortality and disability. Nowadays we know many different scores that predict stroke risk,butthe most popular is CHA 2 DS 2 -VASc risk score. At the same time, this score does not have high predictive accuracyand that is why a lot of modifications with inclusion/deletion of different indicators were introduced. The aim of this review was to estimate the different modifications of CHADS 2 и CHA 2 DS 2 -VASc scores in predicting stroke risk in patients with AF. In this review R 2 CHADS 2 , CHA 2 DS 2 -VASc-R, CHA 2 DS 2 -VA, mCHA 2 DS 2 -VASc and CHA 2 DS 2 -VAK scores are evaluated with the use of C-statistics and net reclassification index compared to the original CHA 2 DS 2 -VASc score. The search of studies was performed according to PubMed database (https://pubmed.ncbi.nlm.nih.gov/) from 2011 until 2021 years. In this review were included studies written in English with free full text. Literature reviews, books, abstracts books, studies performed on less than 900 patients and studies without C-statistics data available were excluded from this review. Despite of the numerous attempts to improve the quality of CHA 2 DS 2 -VASc score, existing modifications nowadays could not become more popular in clinical practice. At the same time, developing of the new score systems, that will have better predictive values in stroke prognosis than CHA2DS2-VASc score, is still an actual problem in modern cardiology.