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The dissemination and growth of a line of AKR mouse lymphoma cells serially transplanted in isologous hosts have been examined by spleen colony assay. Normal recipients were given intravenous injections of 106 lymphoma cells. The number of cells with colony-forming capacity in suspensions of spleen, femoral marrow, thymus, and blood 2 hours later was a fraction (<it>f</it>) of the number of colony-forming cells injected. Measured values of this fraction were: <link locator="32-5-1145-eq001"> Between 2 hours and 7 days after the injection, the number of colony-forming cells in each organ increased exponentially with a doubling time of 11.2 hours. Animals died with wide-spread lymphoma cell involvement on the 7th day. The properties of these lymphoma colony-forming cells are compared with those of the colony-forming cells in normal murine fetal liver, marrow, and spleen.
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Bruce et al. (1964) studied this question.
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