What question did this study set out to answer?

To assess the influence of sex disparities on clinical manifestations and disease outcomes among patients with systemic lupus erythematosus.

July 1, 2016MedicineOpen Access

Impact of sex disparities on the clinical manifestations in patients with systemic lupus erythematosus

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To assess the influence of sex disparities on clinical manifestations and disease outcomes among patients with systemic lupus erythematosus.
Literature search across MEDLINE/PubMed and EMBASE databases conducted through January 2016 for relevant clinical manifestation endpoints.
Meta-analysis of 16 studies comprising 11,934 patients with systemic lupus erythematosus (10,331 females and 1,603 males; average female-to-male ratio of 9.3:1) utilizing fixed- or random-effects models in RevMan 5.3.
Female patients had significantly higher frequencies of alopecia (OR 0.36, 95% CI 0.29–0.46, P < 0.00001), photosensitivity (OR 0.72, 95% CI 0.63–0.83, P < 0.00001), oral ulcers (OR 0.70, 95% CI 0.60–0.82, P < 0.00001), and malar rash (OR 0.68, 95% CI 0.53–0.88, P = 0.003).
Male patients exhibited a significantly higher risk of renal involvement (OR 1.51, 95% CI 1.31–1.75, P < 0.00001), alongside significant variations in serositis (OR 1.52, 95% CI 1.25–1.84, P < 0.0001) and pleurisies (OR 1.26, 95% CI 1.07–1.48, P = 0.006).

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Implication

Meta-analysis reveals distinct sex-specific clinical profiles in systemic lupus erythematosus, indicating the necessity of sex-tailored management strategies.

Cite This Study

Boodhoo et al. (2016) studied this question.

synapsesocial.com/papers/6a17273a2fcf950e0005b876 https://doi.org/10.1097/md.0000000000004272

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Implication

Meta-analysis reveals distinct sex-specific clinical profiles in systemic lupus erythematosus, indicating the necessity of sex-tailored management strategies.

Impact of sex disparities on the clinical manifestations in patients with systemic lupus erythematosus

Key Points

Discussion

Implication

Cite This Study

Impact of sex disparities on the clinical manifestations in patients with systemic lupus erythematosus

Key Points

Discussion

Implication

Cite This Study

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