Key result
LVET is reduced in dilated cardiomyopathy and correlates with LV systolic function and functional capacity.
Why the study?
To evaluate the value of left ventricular ejection time for detecting LV systolic dysfunction and assessing functional capacity and clinical severity in patients with dilated cardiomyopathy.
Does left ventricular ejection time correlate with left ventricular systolic function and functional capacity in patients with dilated cardiomyopathy?
Observational (n=131)
Does left ventricular ejection time correlate with left ventricular systolic function and functional capacity in patients with dilated cardiomyopathy?
p-value: p=0.002
Left ventricular ejection time is a simple echocardiographic measure that correlates with systolic dysfunction and clinical severity in patients with dilated cardiomyopathy.
LVET was associated with systolic function and capacity in DCM; hypothesis-generating and requires prospective validation before clinical adoption.
Background and aim Left ventricular ejection time (LVET) was used to evaluate left ventricular function. Transthoracic echocardiogram was done, and parameters of LV systolic function by utilizing tissue Doppler imaging and two-dimensional strain were obtained. Moreover, the New York Heart Association (NYHA) functional class and 6 min walk test (6MWT) was investigated intending to detect the LVET value in the detection of LV systolic dysfunction in patients with dilated cardiomyopathy (DCM) and its relation to a functional capacity to assess the clinical severity of systolic heart failure. Patients and methods The enrolled 131 cases (101 myopathic patients and 30 case as a control). All cases do complete transthoracic echocardiogram to assess LV dimensions, volumes, and systolic function. Parameters of LV systolic function were compared in both groups. LVET was calculated, compared, and correlated with LV systolic function, NYHA class, and 6MWT. Results The LV volumes of patients with DCM were significantly elevated ( P <0.001), while their LV systolic function was significantly reduced. Additionally, the cardiomyopathic group revealed a significant reduction in LVET in comparison to the control group ( P =0.002). Moreover, the LVET correlates significantly with parameters of LV systolic function [LVEF by M-mode ( r =0.01), LVEF by two-dimensional ( r =0.17), left ventricular global longitudinal strain ( r =0.09), left ventricular systolic velocity ( r =0.20)]. Furthermore, LVET connected to NYHA functional class and 6MWT ( r =−0.06, P <0.0001, r =0.04, P =0.01, respectively). Conclusions In individuals having DCM, LVET is a simple and valuable measure to diagnose LV systolic dysfunction as well as it has potential implications for assessing the clinical severity of heart failure.
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Shahawy et al. (2024) conducted an observational in Dilated cardiomyopathy (n=131). Left ventricular ejection time (LVET) measurement vs. Control group was evaluated on LVET value and its correlation with LV systolic function, NYHA class, and 6MWT (p=0.002). Left ventricular ejection time was significantly reduced in patients with dilated cardiomyopathy compared to controls (P=0.002) and correlated with LV systolic function and functional capacity.
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