Key result
Flecainide treatment in three pregnant women with pre-excited atrial fibrillation resulted in no arrhythmia recurrence and no adverse events.
Why the study?
Pregnancy is associated with an increased incidence of cardiac arrhythmias, but data regarding the efficacy and safety of anti-arrhythmic agents to prevent pre-excited AF in pregnant women are limited.
Does flecainide prevent arrhythmia recurrence safely in pregnant women with pre-excited atrial fibrillation?
Case Report (n=3)
Does flecainide prevent arrhythmia recurrence safely in pregnant women with pre-excited atrial fibrillation?
Flecainide appears safe and effective for preventing recurrence of pre-excited atrial fibrillation in pregnant women with Wolff-Parkinson-White syndrome.
Flecainide may warrant consideration in select pregnant patients with pre-excited AF; leaves open confirmation of safety and efficacy.
BACKGROUND: Pregnancy is associated with an increased incidence of cardiac arrhythmias likely due to hormonal, haemodynamic, and autonomic changes. Yet, there is little data available regarding the efficacy and safety of anti-arrhythmic agents to prevent pre-excited atrial fibrillation (AF) in pregnant women. CASE SUMMARY: We report on three pregnant women who developed AF rapidly conducted to the ventricle through an overt accessory pathway as the first manifestation of Wolff-Parkinson-White syndrome. DISCUSSION: All patients were treated with flecainide with neither arrhythmias recurrence nor adverse events of the treatment. Mechanisms of action and clinical efficacy of flecainide are discussed.
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Chauveau et al. (2019) conducted a case report in Pre-excited atrial fibrillation in Wolff-Parkinson-White syndrome (n=3). Flecainide was evaluated on Arrhythmia recurrence and adverse events. Flecainide treatment in three pregnant women with pre-excited atrial fibrillation resulted in no arrhythmia recurrence and no adverse events.
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