Key result
A diagnostic algorithm using ECG right ventricular strain and NT-proBNP increased specificity for excluding pre-capillary PH to 19.3% (p=0.0009) while maintaining 100% sensitivity.
Why the study?
Does a noninvasive diagnostic algorithm using ECG and NT-proBNP safely exclude pre-capillary pulmonary hypertension in patients with echocardiographic suspicion?
Observational (n=372)
Does a noninvasive diagnostic algorithm using ECG and NT-proBNP safely exclude pre-capillary pulmonary hypertension in patients with echocardiographic suspicion?
p-value: p=0.0009
Adding ECG right ventricular strain and NT-proBNP to echocardiography safely excludes pre-capillary pulmonary hypertension, potentially reducing unnecessary right heart catheterisations by approximately 20%.
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May aid noninvasive exclusion of pre-capillary PH; hypothesis-generating and requires prospective validation before practice change.
Bonderman et al. (2010) conducted an observational in Suspicion of pre-capillary pulmonary hypertension (n=372). Diagnostic algorithm using ECG right ventricular strain and NT-proBNP vs. Echocardiography alone was evaluated on Specificity for excluding pre-capillary PH (p=0.0009). A diagnostic algorithm using ECG right ventricular strain and NT-proBNP increased specificity for excluding pre-capillary PH to 19.3% (p=0.0009) while maintaining 100% sensitivity.
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