Key result
Among 118 stroke survivors, female sex, advanced age, and prestroke factors including smoking and functional dependence were associated with new-onset depression poststroke.
Why the study?
What factors are associated with new-onset depression in stroke survivors?
Cohort (n=118)
What factors are associated with new-onset depression in stroke survivors?
Female sex, advanced age, smoking, and functional dependence are associated with new-onset depression after stroke, highlighting the importance of prestroke factors in risk stratification.
May inform risk stratification among stroke survivors; leaves open whether modifying prestroke factors prevents depression.
To better identify stroke survivors at risk for depression who may benefit from early prevention through targeted strategies in the acute-subacute poststroke period, we examined 118 Framingham Heart Study stroke survivors with longitudinal prestroke depression assessments. Among those who developed poststroke depression, most lacked a history of depressive symptoms 5 years prior to their stroke. Sex (female), advanced age, and prestroke factors (smoking and functional dependence) were associated with new-onset depression poststroke. These findings suggest fully characterizing and accounting for prestroke factors, including psychosocial and behavioral determinants, may inform the predictive modeling needed to determine whether targeted preventive trials early in stroke recovery will improve stroke outcomes.
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Salinas et al. (2016) conducted a cohort in Stroke survivors (n=118). Risk factors (female sex, advanced age, smoking, functional dependence) was evaluated on New-onset depression poststroke. Among 118 stroke survivors, female sex, advanced age, and prestroke factors including smoking and functional dependence were associated with new-onset depression poststroke.
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