Key result
Women with acute stroke have ~16% fewer favorable functional outcomes than men despite similar care.
Why the study?
Prior studies on gender differences in stroke have yielded diverse results, leaving a need for research in different populations, including developing countries.
Does female gender affect stroke severity, acute management, and clinical outcomes in patients presenting with acute stroke?
Cross-Sectional (n=4,620)
No
Does female gender affect stroke severity, acute management, and clinical outcomes in patients presenting with acute stroke?
Absolute Event Rate: 47.3% vs 56.1%
p-value: p=<0.001
In a developing country cohort, women presenting with acute stroke had worse baseline severity and 3-month functional outcomes compared to men, despite receiving similar acute revascularization services.
Women with acute stroke may face unmeasured post-acute disparities; leaves open sex-specific recovery factors in developing-country cohorts.
BACKGROUND: Several studies have addressed gender differences in stroke. Yet, results are diverse, and research is still required in different populations. So, this study investigates variation in stroke according to gender in a developing country. METHODS: This is a registry-based, retrospective observational cross-sectional study comparing men and women as regards age, risk factors, stroke severity, quality of services, and stroke outcome. RESULTS: Data analyzed comprised 4620 patients. It was found that men outnumbered women, while women had an older age, more prevalence of hypertension and atrial fibrillation, with severer strokes and worse outcomes. However, there was no gender difference in promptness nor frequency of administration of revascularization therapies. CONCLUSION: Despite the gender difference in risk factors and stroke severity, we could not detect any significant disparity in acute stroke services provided to either gender. Among age categories in women, we identified differences in acute ischemic stroke subtypes, and acute management in favor of older age.
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Nahas et al. (2023) conducted a cross-sectional in Acute stroke (n=4,620). Female gender vs. Male gender was evaluated on Favorable outcome (mRS ≤ 2) at 3 months (p=<0.001). Women with acute stroke had significantly less favorable functional outcomes at 3 months compared to men (47.3% vs 56.1%, p<0.001), despite receiving similar acute stroke services.
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