Key result
Female stroke patients have ~25% greater absolute pre-existing disability than men despite similar overall recovery.
Why the study?
Sex-based differences in stroke outcomes have been well documented, with women often experiencing more severe strokes and poorer recoveries.
Do stroke outcomes, severity, and baseline functional status differ between male and female patients?
Population
Adult patients with confirmed acute stroke admitted to Milton Keynes University Hospital from 2022 to 2023
Comparison
Women vs men
Design
Retrospective cohort study
Follow-up
At discharge
Authors
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Sex differences in stroke outcomes warrant continued monitoring in routine care; leaves open whether targeted strategies improve recovery in women.
Cohort (n=271)
No
Do stroke outcomes, severity, and baseline functional status differ between male and female patients?
Absolute Event Rate: 54.6% vs 79.4%
p-value: p=0.0001
Women presenting with acute stroke are significantly older and have greater baseline disability than men, highlighting the need for sex-specific considerations in stroke management.
Ibzea et al. (2025) conducted a cohort in Acute stroke (n=271). Female sex vs. Male sex was evaluated on Pre-stroke functional status (mRS = 0) (p=0.0001). Women presenting with acute stroke had significantly greater pre-existing disability compared to men (54.6% vs 79.4% with no symptoms), though overall stroke severity and recovery did not differ significantly.
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