Key result
Combined therapy of amlodipine and quercetin significantly improved cardiac electrophysiologic functions and preserved ATP and GSH contents in rats with ischaemia/reperfusion injury.
Why the study?
Does co-administration of quercetin and amlodipine improve cardioprotection in myocardial ischaemia/reperfusion injury in rats?
Does co-administration of quercetin and amlodipine improve cardioprotection in myocardial ischaemia/reperfusion injury in rats?
Co-administration of quercetin with amlodipine enhances cardioprotection against myocardial ischaemia/reperfusion injury in a rat model.
Preclinical data do not change practice; leaves open translation of quercetin-amlodipine cardioprotection to human ischaemia/reperfusion injury.
OBJECTIVES: To investigate the possible modification of the cardioprotective effect of amlodipine when co-administered with quercetin in myocardial ischaemia/reperfusion-induced functional, metabolic and cellular alterations in rats. METHODS: Oral doses of amlodipine (15 mg/kg) and quercetin (5 mg/kg), alone or in combination, were administered once daily for 1 week. Rats were then subjected to myocardial ischaemia/reperfusion (35(min)/10(min)). Heart rates and ventricular arrhythmias were recorded during ischaemia/reperfusion progress. At the end of reperfusion, activities of plasma creatine kinase (CK) and cardiac myeloperoxidase were determined. In addition, cardiac contents of lactate, ATP, thiobarbituric acid reactive substances (TBARS), reduced glutathione (GSH) and total nitrate/nitrite (NO(x)) were estimated. Finally, histological examination was performed to visualize the protective cellular effects of different pretreatments. KEY FINDINGS: Combined therapy provided significant improvement in the amlodipine effect toward preserving cardiac electrophysiologic functions, ATP and GSH contents as well as reducing the elevated plasma CK, cardiac TBARS and NO(x) contents. CONCLUSION: Quercetin could add benefits to the cardioprotective effect of amlodipine against injury induced in the heart by ischaemia/reperfusion.
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Ahmed et al. (2009) studied Myocardial ischaemia/reperfusion injury. Amlodipine and quercetin combination vs. Amlodipine alone, quercetin alone was evaluated on Cardiac electrophysiologic functions, ATP and GSH contents, plasma CK, cardiac TBARS and NOx contents. Combined therapy of amlodipine and quercetin significantly improved cardiac electrophysiologic functions and preserved ATP and GSH contents in rats with ischaemia/reperfusion injury.
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