Endogenous Y RNAs serve as conserved RIG-I ligands that contribute to antiviral immunity and are targeted by HIV-1 through changes in cellular RNA 5'-triphosphorylation.
Absolute Event Rate: 0% vs 0%
, inducing a transcriptome-wide change of cellular RNA 5'-triphosphorylation that licenses Y RNA immunogenicity. Overall, our work uncovers the contribution of endogenous RNAs to antiviral immunity and demonstrates the importance of this pathway in HIV-1 infection.
Vabret et al. (Sat,) reported a other. Endogenous Y RNAs serve as conserved RIG-I ligands that contribute to antiviral immunity and are targeted by HIV-1 through changes in cellular RNA 5'-triphosphorylation.