Key result
Structural organization and dynamics of actin filaments in locomoting heart fibroblasts reveal a novel graded polarity organization in long, overlapping bundles that has implications for motile force.
Population
Primary locomoting heart fibroblasts and nonlocomoting PtK2 cells
Design
Preclinical
Authors
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Novel graded actin polarity in cardiac fibroblasts; leaves open its role in vivo motility and cardiac repair.
The study identifies a novel graded polarity organization of actin filament bundles in locomoting heart fibroblasts, providing insights into the generation of motile force during cell locomotion.
Cramer et al. (1997) studied Locomoting heart fibroblasts. Structural organization and dynamics of actin filaments in locomoting heart fibroblasts reveal a novel graded polarity organization in long, overlapping bundles that has implications for motile force.
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