What question did this study set out to answer?

To determine whether the characteristic adiposity and hyperinsulinemia observed in adult Indians are already present at birth.

December 1, 2002The Journal of Clinical Endocrinology & Metabolism

Adiposity and Hyperinsulinemia in Indians Are Present at Birth

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To determine whether the characteristic adiposity and hyperinsulinemia observed in adult Indians are already present at birth.
Measured body size, skinfold thickness, and cord blood leptin and insulin concentrations in 157 urban Indian newborns in Pune, India, and 67 white Caucasian newborns in London, UK.
Evaluated maternal anthropometric measurements in both cohorts to assess maternal contributions to fetal outcomes.
Indian neonates had significantly lower median birth weight (2805 g vs. 3475 g; P < 0.001; -1.52 SD score; 95% CI, -1.66 to -1.42) and smaller circumferences, but central subscapular skinfold was relatively preserved (-0.32 SD score; 95% CI, -0.43 to -0.20) compared with triceps skinfold (-0.86 SD score; 95% CI, -0.97 to -0.75).
Cord plasma insulin (median 34.7 pmol/L in Pune vs. 20.8 pmol/L in London) and leptin (median 6.2 ng/mL vs. 6.4 ng/mL) concentrations were significantly elevated in Indian newborns after adjustment for birth weight.

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Implication

Comparative study reveals relative adiposity and hyperinsulinemia in Indian newborns compared to Caucasian infants, indicating intrauterine origins of adult insulin resistance.

Cite This Study

Yajnik et al. (2002) studied this question.

synapsesocial.com/papers/6a1749b65c24d7ef898d7fc9 https://doi.org/10.1210/jc.2002-020434

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Implication

Comparative study reveals relative adiposity and hyperinsulinemia in Indian newborns compared to Caucasian infants, indicating intrauterine origins of adult insulin resistance.

Adiposity and Hyperinsulinemia in Indians Are Present at Birth

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Discussion

Implication

Cite This Study

Adiposity and Hyperinsulinemia in Indians Are Present at Birth

Key Points

Discussion

Implication

Cite This Study

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