Key result
Dorsolateral prefrontal cortex integrates uncertainty management, movement facilitation, and cardiovascular control.
Why the study?
Although the dorsolateral prefrontal cortex is increasingly targeted by noninvasive brain stimulation in neuropsychiatric disorders, the rationale for this therapeutic modulation remains elusive.
This review highlights the dorsolateral prefrontal cortex as a key integration center for cardiovascular control, providing a rationale for neuromodulation therapies in neuropsychiatric disorders.
Answers are grounded in this paper and cite their sources.
May inform neuromodulation targets in neuropsychiatric disease; leaves open whether DLPFC targeting alters cardiovascular outcomes.
The dorsolateral prefrontal cortex (dlPFC) is increasingly targeted by various noninvasive transcranial magnetic stimulation or transcranial current stimulation protocols in a range of neuropsychiatric and other brain disorders. The rationale for this therapeutic modulation remains elusive. A model is proposed, and up-to-date evidence is discussed, suggesting that the dlPFC is a high-level cortical centre where uncertainty management, movement facilitation, and cardiovascular control processes are intertwined and integrated to deliver optimal behavioural responses in particular environmental or emotional contexts. A summary of the state-of-the-art in the field is provided to accelerate the development of emerging neuromodulation technologies for brain stimulation and recording for patients with mood, sleep, and cognitive disorders in our ageing population.
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Marcinkowska et al. (2025) conducted a review in Cardiovascular control and neuropsychiatric disorders. Dorsolateral prefrontal cortex (dlPFC) modulation was evaluated. The dorsolateral prefrontal cortex acts as a high-level cortical center where uncertainty management, movement facilitation, and cardiovascular control processes are intertwined and integrated.
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