Key result
Repeated treadmill-exercise stress testing in pediatric patients demonstrated high reproducibility of QTc at rest and after exercise, with intraclass correlation coefficients of 0.84-0.85 in LQTS.
Why the study?
Does repeated treadmill-exercise stress testing yield reproducible corrected QT intervals (QTc) in pediatric patients with long QT syndrome?
Observational (n=35)
Does repeated treadmill-exercise stress testing yield reproducible corrected QT intervals (QTc) in pediatric patients with long QT syndrome?
Effect estimate: ICC 0.84-0.85
The corrected QT interval shows high reproducibility both at rest and after exercise in pediatric patients with and without long QT syndrome.
Supports QTc reproducibility via repeated exercise testing in pediatric LQTS; hypothesis-generating and requires larger prospective validation before clinical adoption.
Reproducibility of corrected QT interval (QTc), especially QTc after exercise, has not been thoroughly investigated. We reviewed charts of pediatric patients who underwent treadmill-exercise stress testing without medication multiple times within 1 year. In patients with long-QT syndrome (LQTS; n = 22), the discrepancy in QTc between two treadmill exercise stress tests using Fridericia's formula was 14 ± 12 ms at rest, 13 ± 12 ms 4 min after exercise, with a maximum of 14 ± 12 ms after exercise. There was no statistically significant difference in QTc between the two tests. Intraclass correlation coefficients (ICC) were 0.84, 0.85, and 0.85, respectively. In controls (n = 13), the discrepancy in QTc was 18 ± 12 ms at rest, 14 ± 7 ms 4 min after exercise, with a maximum of 14 ± 9 ms after exercise. There was no significant difference in QTc between the two tests. ICC were 0.78, 0.80, and 0.80, respectively. QTc calculated using Bazett's formula also showed high reproducibility. Reproducibility of QTc in children is high at rest and after exercise.
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Ogawa et al. (2016) conducted an observational in Pediatric genotyped long QT syndrome (n=35). Repeated treadmill-exercise stress testing vs. Healthy controls was evaluated on Reproducibility of corrected QT interval (QTc) between two treadmill exercise stress tests (ICC 0.84-0.85). Repeated treadmill-exercise stress testing in pediatric patients demonstrated high reproducibility of QTc at rest and after exercise, with intraclass correlation coefficients of 0.84-0.85 in LQTS.
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