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August 1, 2001HeartOpen Access

Comparison of formulae for heart rate correction of QT interval in exercise ECGs from healthy children

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Why the study?

How do different heart rate correction formulae affect the calculated QTc interval during and after exercise in healthy children?

Population

54 healthy children, median age 9.9 years (range 5.05-14.9 years)

Comparison

Graded physical exercise until heart rate… vs Baseline and recovery stages

Design

Cross-sectional

Follow-up

6 minutes after exercise

Authors

ABAvram BenatarVrije Universiteit Brussel

Discussion

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Overview

Formula choice drives opposing QTc shifts at peak exercise in children; leaves open optimal correction for repolarization assessment.

Structured PICO

How do different heart rate correction formulae affect the calculated QTc interval during and after exercise in healthy children?

P
Population
54 healthy children, median age 9.9 years (range 5.05-14.9 years)
I
Intervention
Graded physical exercise (bicycle ergometer or treadmill) until heart rate reached > 85% of expected maximum for age
C
Comparator
Baseline (rest) and recovery stages (1, 2, 4, and 6 minutes after exercise)
O
Outcome
Differences in QTc values calculated using Bazett, Hodges, Fridericia, and Framingham formulae at rest, peak exercise, and recoverysurrogate

The choice of QT correction formula significantly alters QTc values during and after exercise in children, highlighting that ad hoc selection of formulae may bias results in repolarization studies.

Cite This Study

Avram Benatar (2001) studied this question.

synapsesocial.com/papers/6a8aa74293d6d5583ccc1be5https://doi.org/10.1136/heart.86.2.199
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Also Consider

Synapse has enriched one closely related paper. Consider it for comparative context:

  1. 1Rate adaptation of QT intervals during and after exercise in children with congenital long QT syndrome1998 · 59 citations