April 1, 1988Journal of VirologyOpen Access

Physical characterization of the herpes simplex virus latency-associated transcript in neurons

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Population

Murine sensory nerve ganglia latently infected with herpes simplex virus type 1

Design

Preclinical

Authors

Discussion

Maps HSV-1 LAT termini in murine ganglia; extends transcript characterization but leaves open human latency relevance.

Population

Murine sensory nerve ganglia latently infected with herpes simplex virus type 1

Intervention

RNA transfer (Northern) blot analysis, in situ hybridization, S1 nuclease and primer extension mapping

Outcome

Physical characterization of the latency-associated transcript (LAT)

The study mapped the 5' and 3' ends of the major latency-associated transcript of HSV-1 in latently infected murine sensory nerve ganglia.

Wagner et al. (1988) studied this question.

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