Higher BMI at age 25 was associated with an increased risk of incident coronary heart disease compared to the lowest BMI category (RR 2.44; 95% CI 1.61-3.69) in Japanese-American men.
Cohort (n=6,176)
Does BMI at age 25 and subsequent weight change affect the risk of incident coronary heart disease in Japanese-American men?
Higher relative weight in early adulthood and early weight gain are positively associated with a higher risk of incident coronary heart disease later in life.
Effect estimate: RR 2.44 (95% CI 1.61-3.69)
Risk of coronary heart disease (CHD) among the Honolulu Heart Program participants was examined in relation to body mass index (BMI) at age 25 and two subsequent periods of weight change: age 25 to examination I (1965-1968) and examination I to examination III (1971-1974). During a maximum follow-up period of 17 years after examination III, there were 479 incident cases of CHD among the study sample of 6,176 Japanese-American men. Levels of BMI at age 25 were positively related to CHD incidence after statistical control for age, smoking, and subsequent weight change. Relative risk between the lowest and highest BMI categories was 2.44 (95% confidence interval (CI) 1.61-3.69). Compared with a weight change of less than 2.5 kg between age 25 and examination I, relative risks were 1.41 (95% CI 1.00-1.97) for a weight gain between 2.6 and 5 kg, 1.60 (95% CI 1.22-2.11) for a weight gain between 5.1 and 10 kg, and 1.75 (95% CI 1.32-2.33) for a weight gain of more than 10 kg. During the examination I-III period, in contrast, the highest risk of CHD was found in men who lost the greatest amount of weight; the relative risk of CHD for men who lost more than 2.5 kg was 1.25 (95% CI 0.98-1.60). The authors conclude that levels of relative weight in early adulthood were positively related to risk of CHD occurring much later in the lives of these men. The association between CHD incidence and weight change appeared to be modified by age, with higher risks for earlier weight gain and later weight loss in the lives of these men.
Galanis et al. (Sun,) conducted a cohort in Coronary heart disease (n=6,176). Highest BMI category at age 25 vs. Lowest BMI category at age 25 was evaluated on Incident cases of CHD (RR 2.44, 95% CI 1.61-3.69). Higher BMI at age 25 was associated with an increased risk of incident coronary heart disease compared to the lowest BMI category (RR 2.44; 95% CI 1.61-3.69) in Japanese-American men.
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