Key result
BMI up to 35 linked to lower ICU mortality, while higher levels increase risk.
Why the study?
Although studies have assessed the relationship between body mass index and intensive care unit mortality, previous results were inconsistent.
Does Body Mass Index impact the risk of mortality in patients admitted to the intensive care unit?
Meta-Analysis (n=238,961)
Does Body Mass Index impact the risk of mortality in patients admitted to the intensive care unit?
In ICU patients, a BMI up to 35 is associated with decreased mortality, while a BMI > 35 is associated with increased mortality, demonstrating a nonlinear relationship.
Answers are grounded in this paper and cite their sources.
ICU mortality risk assessment should incorporate BMI cautiously; leaves open causal role and need for prospective trials.
INTRODUCTION: Both low and high body mass index (BMI) are associated with mortality in the intensive care unit (ICU). Although many studies have been done to determine the relationship between BMI and risk of mortality in the ICU, their results were inconsistent. This study aimed to conduct a dose-response meta-analysis of published observational studies to assess the effect of BMI on the risk of mortality in patients admitted to the ICU. METHODS: PubMed, Scopus, and Google Scholar were searched to identify articles up to May 2019. A total of 31 relevant articles, with 238,961 patients and a follow-up period of 1 month to 11 years, were analyzed. RESULTS: ) increase in BMI (odds ratio: 0.99; 95% CI, 0.98-0.99). In addition, nonlinear analysis showed a decrease in risk of mortality for a BMI of 35 (P < .001) and then increased the risk of mortality with a BMI > 35 (P < .001). CONCLUSION: This dose-response meta-analysis revealed that a BMI ≤ 35 can be a protective agent against mortality, but a BMI > 35 is a life-threatening factor in patients admitted to the ICU.
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Khalooeifard et al. (2020) conducted a meta-analysis in Patients admitted to the ICU (n=238,961). Body Mass Index (BMI) vs. Different BMI levels was evaluated on Mortality (OR 0.99, 95% CI 0.98-0.99, p=<.001). A dose-response meta-analysis revealed that increasing BMI up to 35 is associated with decreased ICU mortality (OR 0.99; 95% CI 0.98-0.99), whereas a BMI > 35 increases mortality risk (P<0.001).
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