Why the study?
Is body mass index associated with hospital mortality in mechanically ventilated adults with acute lung injury?
Population
1,488 mechanically ventilated adults with acute lung injury (ALI) from 106 ICUs in 84 hospitals
Comparison
Body mass index as a continuous and categorical… vs Normal BMI group (for categorical analysis)
Design
Cohort
Follow-up
Until hospital discharge
Authors
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Supports obesity paradox in ventilated ALI; hypothesis-generating and should not yet change risk stratification.
Is body mass index associated with hospital mortality in mechanically ventilated adults with acute lung injury?
In mechanically ventilated adults with acute lung injury, lower BMI is associated with higher hospital mortality, while overweight and obese BMIs are associated with lower mortality, demonstrating an obesity paradox.
O’Brien et al. (2006) studied this question.
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