Key result
Acupuncture lowers blood pressure in essential hypertension by regulating the renin-angiotensin-aldosterone system, vascular endothelium, oxidative stress, and neuroendocrine system.
Why the study?
Acupuncture can lower blood pressure in patients with hypertension, but the mechanism of its action is unclear.
What are the mechanisms by which acupuncture lowers blood pressure in patients with essential hypertension?
What are the mechanisms by which acupuncture lowers blood pressure in patients with essential hypertension?
Acupuncture may lower blood pressure in essential hypertension through multiple mechanisms including RAAS, vascular endothelium, oxidative stress, and neuroendocrine regulation.
May support mechanistic exploration of acupuncture in hypertension; hypothesis-generating and should not yet change practice.
Essential hypertension has a high incidence worldwide, and patients with essential hypertension endure a lifetime of medication, leading to a heavy economic burden on the patient's family and causing serious impacts on the patient's quality of life. Much evidence has demonstrated that acupuncture as an adjunctive therapy can lower blood pressure in patients with hypertension, but the mechanism of its action is unclear. This article reviews the research from 2000 to 2018 regarding the mechanism of acupuncture for hypertension, and we summarize the current knowledge about using acupuncture for hypertension. We found that the mechanism whereby acupuncture lowers blood pressure is related to the regulation of renin-angiotensin-aldosterone system, vascular endothelium, oxidative stress, neuroendocrine system, and so on. Besides, there may be cross-talk between multiple systems and multiple targets. We also investigate the influence factors of acupuncture for hypertension. These results may provide evidence and research ideas for the treatment of hypertension via acupuncture.
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Li et al. (2019) conducted a review in Essential hypertension. Acupuncture was evaluated. Acupuncture lowers blood pressure in essential hypertension by regulating the renin-angiotensin-aldosterone system, vascular endothelium, oxidative stress, and neuroendocrine system.
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