Key result
Left ventricular diastolic dysfunction was present in 57% of asymptomatic patients with type 2 diabetes mellitus and was significantly associated with older age, longer disease duration, and higher HbA1c.
Why the study?
Left ventricular diastolic dysfunction is an early, asymptomatic stage of diabetic cardiomyopathy that can progress to heart failure, prompting evaluation of its presence and associations with glycemic control, disease duration, and microangiopathy in asymptomatic type 2 diabetes.
Is left ventricular diastolic dysfunction associated with glycaemic control and disease duration in asymptomatic patients with type 2 diabetes mellitus?
Cross-Sectional (n=100)
No
Is left ventricular diastolic dysfunction associated with glycaemic control and disease duration in asymptomatic patients with type 2 diabetes mellitus?
Left ventricular diastolic dysfunction is highly prevalent in asymptomatic type 2 diabetes patients and is strongly associated with poor glycaemic control and longer disease duration.
May prompt earlier echocardiography in long-standing uncontrolled type 2 diabetes; leaves open causal links and need for prospective outcome trials.
Diabetes Mellitus (DM) is a disease with multi-system complications. Left ventricular diastolic dysfunction (LVDD) is an early stage of diabetic cardiomyopathy that can develop to heart failure. It has no clinical symptoms and can be easily diagnosed with echocardiography. The study aims to evaluate the LVDD in Type-2 DM with no symptoms of cardiovascular disease and its association with glycaemic control (HbA1c), DM duration, and microangiopathy. The cross-sectional hospital-based study included 100 asymptomatic patients with type 2 DM without evidence of cardiovascular involvement were studied. LVDD was evaluated by doppler echocardiography, which included E/A ratio, assessed in relation with age, sex, duration of diabetes and HbA1c level. LVDD was present in 57 % of the type 2 DM patients with males accounting for the majority of cases (63.2%). Diastolic dysfunction was more common in patients on oral hypoglycaemic agents (78%), insulin (2%) and/or both (19%). There was a linear progression of diastolic dysfunction with the increase age group (P = 0.001). LVDD was significantly associated with uncontrolled diabetes as measured by HbA1c levels with higher number patients among HbA1c >8.5 (71.9%; P = 0.001) and a longer duration of DM with highest among 6 -10 years (38.6%; P = 0.001).
No takes yet. Share an insight, caveat, or question.
Chidananda et al. (2022) conducted a cross-sectional in Type 2 Diabetes Mellitus (n=100). Doppler Echocardiography was evaluated on Prevalence of left ventricular diastolic dysfunction (LVDD). Left ventricular diastolic dysfunction was present in 57% of asymptomatic patients with type 2 diabetes mellitus and was significantly associated with older age, longer disease duration, and higher HbA1c.
Synapse has enriched 5 closely related papers on similar clinical questions. Consider them for comparative context: