Key result
Three-dimensional echocardiography demonstrated significant agreement with cardiovascular magnetic resonance for assessing right ventricular end-systolic volume (r=0.80, P<0.0001) in PAH patients.
Why the study?
The right ventricle plays a crucial prognostic role in pulmonary arterial hypertension, prompting correlation of 3-D Echo and CMR RV parameters and their relation to clinical conditions.
Does three-dimensional echocardiography agree with cardiovascular magnetic resonance for assessing right ventricular volume and function in patients with pulmonary arterial hypertension?
Observational (n=58)
Does three-dimensional echocardiography agree with cardiovascular magnetic resonance for assessing right ventricular volume and function in patients with pulmonary arterial hypertension?
Three-dimensional echocardiography demonstrates significant agreement with CMR for assessing right ventricular volume and function in PAH patients, supporting its broader use in routine clinical evaluation.
Supports 3D echocardiography for RV assessment in PAH; leaves open need for prospective validation before wider adoption.
AIM: To correlate 3-D Echo and CMR RV parameters and to verify whether they are similarly related to the clinical conditions of patients with pulmonary arterial hypertension (PAH), a disease in which the RV plays a crucial prognostic role. METHODS: We enrolled 34 consecutive PAH patients followed by our PAH clinics. All patients underwent a 3-D Echo and CMR assessment of RV volumes and functions in the same day. The presence or absence of correlation between major findings was investigated; functional RV parameters were also analyzed in relation to 6-min walking test (6MWT) results and BNP/Nt-proBNP plasma levels. Twenty-four subjects served as controls. RESULTS: Good agreement was found between 3-D Echo and CMR measures of RV volumes [RV-end-diastolic volume (r = 0.72, P < 0.0001), RV-end-systolic volume (ESV) (r = 0.80, P < 0.0001)] and function [RV-EF (r = 0.73, P < 0.0001), RV-ESV/SV (r = 0.83, P = 0.001)] for all the subjects of the study. These correlations were stronger in PAH patients than in control subjects. Importantly, 3-D Echo and CMR RV-EF and RV to pulmonary arterial coupling (RV-ESV/SV) similarly correlated with BNP/Nt-proBNP levels and with functional capacity measured at 6MWT in the PAH patients group. CONCLUSIONS: 3-D Echo demonstrated a significant agreement with CMR in the assessment of RV volume and function in PAH patients. Both techniques showed a similar correlation with clinical and prognostic parameters. The use of 3-D Echo should be amply boosted in the real-world clinical evaluation of PAH patients.
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Lattanzio et al. (2021) conducted an observational in Pulmonary arterial hypertension (n=58). Three-dimensional echocardiography (3-D Echo) vs. Cardiovascular magnetic resonance (CMR) was evaluated on Agreement between 3-D Echo and CMR measures of right ventricular volumes and function (p=<0.0001). Three-dimensional echocardiography demonstrated significant agreement with cardiovascular magnetic resonance for assessing right ventricular end-systolic volume (r=0.80, P<0.0001) in PAH patients.
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