Key result
Increasing paced ventricular rate significantly decreased LAA flow velocities (p<0.01), while regular rhythm at 120 bpm increased total TVI vs irregular rhythm (40.16 vs 30.74 cm, p<0.05).
Why the study?
Does increasing ventricular rate and irregularity reduce left atrial appendage flow velocity in patients with atrial fibrillation?
Does increasing ventricular rate and irregularity reduce left atrial appendage flow velocity in patients with atrial fibrillation?
p-value: p=<0.01
Rapid ventricular rates in atrial fibrillation significantly reduce left atrial appendage flow velocities, potentially predisposing to blood stasis and thrombosis.
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Higher ventricular rates may promote LAA stasis in AF; hypothesis-generating and requires prospective validation before practice change.
Obel et al. (2005) studied Atrial fibrillation (n=12). Pacing at 60, 120, and 150 beats/min in regular and irregular rhythm vs. Different pacing rates and rhythms was evaluated on Peak and mean LAA inflow and outflow velocity, and time-velocity interval (TVI) of LAA flow (p=<0.01). Increasing paced ventricular rate significantly decreased LAA flow velocities (p<0.01), while regular rhythm at 120 bpm increased total TVI vs irregular rhythm (40.16 vs 30.74 cm, p<0.05).
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