Key result
Implantation of three-dimensional cardiospheres in SCID mice with acute infarction improved cell engraftment and myocardial function relative to monolayer-cultured cells.
Why the study?
Does implantation of cardiospheres improve cell engraftment and myocardial function in SCID mice with acute infarction compared to monolayer-cultured cells?
Population
Human endomyocardial biopsy-derived cardiac stem cells and supporting cells; severe combined…
Comparison
Implantation of three-dimensional cardiospheres vs Monolayer-cultured cells or dissociated…
Design
Preclinical
Authors
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Cardiosphere culture may enhance cell therapy in experimental infarction; leaves open translation to clinical stem cell repair.
Does implantation of cardiospheres improve cell engraftment and myocardial function in SCID mice with acute infarction compared to monolayer-cultured cells?
Growing cardiac-derived cells as three-dimensional cardiospheres mimics a stem cell niche, enhancing cell survival and functional benefit after transplantation into infarcted hearts.
Li et al. (2010) studied Acute myocardial infarction (preclinical model). Cardiospheres vs. Monolayer-cultured cells or dissociated cardiospheres was evaluated on Cell engraftment and myocardial function. Implantation of three-dimensional cardiospheres in SCID mice with acute infarction improved cell engraftment and myocardial function relative to monolayer-cultured cells.
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