Why the study?
Is the presence of NAFLD associated with increased subclinical cardiovascular disease markers in patients with type 1 diabetes?
Population
100 patients with type 1 diabetes (mean age 39.4 ± 7.8 years, disease duration 21.7 ± 8.6 years)
Comparison
Presence of non-alcoholic fatty liver disease vs Absence of non-alcoholic fatty liver disease
Design
Cross-sectional
Key result
Type 1 diabetic patients with NAFLD had a significantly greater carotid intima-media thickness compared to those without NAFLD (0.65 vs 0.55 mm; P=0.029), despite a low overall NAFLD prevalence of 12%.
Authors
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NAFLD may flag higher subclinical atherosclerosis risk in T1D; leaves open whether screening or intervention improves outcomes.
Cross-Sectional (n=100)
Is the presence of NAFLD associated with increased subclinical cardiovascular disease markers in patients with type 1 diabetes?
Absolute Event Rate: 0.65% vs 0.55%
p-value: p=0.029
In patients with type 1 diabetes, the presence of NAFLD is associated with increased carotid intima-media thickness, suggesting a link to subclinical cardiovascular disease.
Serra‐Planas et al. (2017) conducted a cross-sectional in Type 1 diabetes (n=100). Non-alcoholic fatty liver disease (NAFLD) vs. No NAFLD was evaluated on Carotid intima-media thickness (CIMT) (p=0.029). Type 1 diabetic patients with NAFLD had a significantly greater carotid intima-media thickness compared to those without NAFLD (0.65 vs 0.55 mm; P=0.029), despite a low overall NAFLD prevalence of 12%.
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