Key result
Aortic valve pathology shifts over four decades as degenerative calcific changes rise to ~27% of cases.
Why the study?
Although aortic valvular disease has various etiologies, calcific aortic valve stenosis has recently been increasing, prompting analysis of four-decade pathological trends in Japan.
Population
4508 patients operated for aortic valvular disease from 1978 to 2022 at a hospital in Japan
Comparison
Trends across four time periods from 1978 to 2022
Design
Single-center retrospective pathological trend analysis
Authors
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May prompt etiology awareness in Japanese aortic valve surgery candidates; extends temporal trends but leaves open global applicability and practice change.
Observational (n=4,508)
No
p-value: p=<0.001
The etiology of aortic valvular disease requiring surgery in Japan has shifted significantly over 40 years, with a marked decrease in rheumatic disease and increases in degenerative calcific and bicuspid etiologies.
Amemiya et al. (2025) conducted an observational in Aortic valvular disease (n=4,508). Trend analysis over four periods vs. Historical periods (1978-1989 vs later periods up to 2022) was evaluated on Trends in the pathological characteristics and etiology of aortic valvular disease (p=<0.001). Pathological analysis over 40 years showed a decrease in chronic rheumatic aortic valve disease from 47% to 14% and an increase in degenerative calcific change from 4% to 27% (p<0.001).
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