Key result
Sympathetic stimulation in perivascular adipose tissue triggers adiponectin release via β3-adrenoceptor activation, and PVAT acts as a noradrenaline reservoir to prevent vessel contraction.
Perivascular adipose tissue regulates arterial tone by releasing adiponectin upon sympathetic stimulation and acting as a noradrenaline reservoir to prevent vasoconstriction.
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May guide PVAT-targeted therapies in vascular disease; leaves open human translation and clinical relevance.
Saxton et al. (2018) studied Vascular resistance / PVAT function. Electrical field stimulation and pharmacological antagonists vs. Control conditions (e.g., PVAT-denuded vessels) was evaluated on Anticontractile effect of PVAT. Sympathetic stimulation in perivascular adipose tissue triggers adiponectin release via β3-adrenoceptor activation, and PVAT acts as a noradrenaline reservoir to prevent vessel contraction.
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