Key result
Platelets drive native aortic stenosis and bioprosthetic valve dysfunction, highlighting the need for antithrombotic trials.
Why the study?
Platelets are implicated in native aortic valve calcific degeneration and bioprosthetic valve dysfunction, but gaps remain between basic platelet biology and clinical preventive and therapeutic implications.
Design
Review
Authors
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Cautions against routine antithrombotic changes in aortic stenosis; leaves open platelet-targeted regimens for dedicated trials.
This review highlights the pathophysiological role of platelets in aortic stenosis and bioprosthetic valve dysfunction, emphasizing the need for further studies on antiplatelet and antithrombotic therapies.
Sellers et al. (2021) conducted a review in Aortic Valve Stenosis and Bioprosthetic Valve Dysfunction. Platelets play a major role in the pathophysiology of native aortic valve stenosis and bioprosthetic valve dysfunction, highlighting the need for further studies on antiplatelet and anticoagulation therapies.
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