Key result
Leaflet thrombosis after TAVI occurred at a pooled incidence of 0.43% per month and significantly increased the risk of stroke (OR 4.21, 95% CI 1.27-13.98).
Why the study?
The incidence, cerebrovascular impact, and clinical or procedural predictors of leaflet thrombosis after TAVI remained to be systematically examined.
Design
Systematic review and meta-analysis
Authors
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Alerts to elevated stroke risk with post-TAVI leaflet thrombosis; supports anticoagulation evaluation but leaves practice change to prospective trials.
Meta-Analysis (n=11,124)
Leaflet thrombosis after TAVI is an infrequent event but significantly increases the risk of stroke, highlighting the potential benefit of oral anticoagulation and CT monitoring in high-risk patients.
D’Ascenzo et al. (2019) conducted a meta-analysis in Transcatheter aortic valve implantation (TAVI) (n=11,124). Leaflet thrombosis vs. No leaflet thrombosis was evaluated on Incidence (clinical and subclinical) of leaflet thrombosis (95% CI 0.21-0.72). Leaflet thrombosis after TAVI occurred at a pooled incidence of 0.43% per month and significantly increased the risk of stroke (OR 4.21, 95% CI 1.27-13.98).
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