Key result
During perinatal development, the heart transitions from a highly glycolytic metabolism in utero to an almost exclusive oxidative metabolism relying on lipids after birth.
Design
Review
Authors
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Informs neonatal cardiac adaptation strategies; leaves open mechanistic validation in congenital disease models.
The perinatal transition of the heart involves a profound metabolic shift from glycolysis to fatty acid oxidation, accompanied by structural compartmentalization and the establishment of the creatine kinase energy shuttle.
Piquereau et al. (2018) conducted a review in Cardiac energy metabolism maturation. During perinatal development, the heart transitions from a highly glycolytic metabolism in utero to an almost exclusive oxidative metabolism relying on lipids after birth.
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