Activation of peroxisome proliferator-activated receptor-α by fenofibrate prevents myocardial dysfunction during endotoxemia in rats*

Q: What is the clinical evidence from this study?

Study design: RCT. Population: endotoxemia. Intervention: fenofibrate vs. standard diet containing no drug. Primary outcome: cardiac contractility and myofilament Ca2+ sensitivity.

Q: What does this research mean for the field?

Fenofibrate pretreatment prevents endotoxemia-induced reductions in cardiac contractility and myofilament Ca2+ sensitivity in a rat model. Novelty: ClaimNovelty.INCREMENTAL. Consensus alignment: ConsensusAlignment.NEUTRAL.

Elsa Jozefowicz; Hélène Brisson; Sandrine Rozenberg; Alexandre Mebazaa; Patrick Gelé; Jacques Callebert; Gilles Lebuffe; B. Vallet; Régis Bordet; B. Tavernier

doi:10.1097/01.ccm.0000256843.75446.a0

January 25, 2007Critical Care Medicine

Activation of peroxisome proliferator-activated receptor-α by fenofibrate prevents myocardial dysfunction during endotoxemia in rats*

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Key result

Fenofibrate pretreatment prevented endotoxemia-induced reductions in cardiac contractility and myofilament Ca2+ sensitivity in a rat model.

Why the study?

Does fenofibrate prevent myocardial dysfunction in a rat model of endotoxemia?

Study Design

Type

RCT

Randomization

randomized

Multicenter

No

Structured PICO

Does fenofibrate prevent myocardial dysfunction in a rat model of endotoxemia?

P

Population

Three-month-old male Wistar rats

I

Intervention

Fenofibrate (0.2%) in standard diet for 14 days prior to 5 mg/kg intravenous lipopolysaccharide (LPS) injection

C

Comparator

Standard diet with no drug for 14 days prior to 5 mg/kg intravenous LPS injection (LPS group) or saline (control group)

O

Outcome

Cardiac contractility (isolated and perfused heart) and myofilament Ca2+ sensitivity (Triton-skinned cardiac fibers)surrogate

Fenofibrate pretreatment prevents endotoxemia-induced cardiac dysfunction and reduction in myofilament Ca2+ sensitivity in rats, potentially mediated by attenuating early peak plasma TNF-alpha.

Implication

Should not change sepsis care; hypothesis-generating for translation to human endotoxemia.

Discussion

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Cite This Study

Jozefowicz et al. (2007) conducted an RCT in endotoxemia. fenofibrate vs. standard diet containing no drug was evaluated on cardiac contractility and myofilament Ca2+ sensitivity. Fenofibrate pretreatment prevented endotoxemia-induced reductions in cardiac contractility and myofilament Ca2+ sensitivity in a rat model.

synapsesocial.com/papers/6a178aa08d470cd992536158 https://doi.org/10.1097/01.ccm.0000256843.75446.a0

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Activation of peroxisome proliferator-activated receptor-α by fenofibrate prevents myocardial dysfunction during endotoxemia in rats*

Study Design

Structured PICO

Implication

Discussion

Cite This Study

Activation of peroxisome proliferator-activated receptor-α by fenofibrate prevents myocardial dysfunction during endotoxemia in rats*

Study Design

Structured PICO

Implication

Discussion

Cite This Study

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