What does this research mean for the field?

PPARalpha is essential for constitutive cardiac mitochondrial fatty acid oxidation and homeostasis, and its absence leads to impaired energy metabolism, decreased ATP under stress, and age-dependent myocardial damage and fibrosis. Novelty: ClaimNovelty.NOVEL_FINDING. Consensus alignment: ConsensusAlignment.NEUTRAL.

July 1, 2000Journal of Biological ChemistryOpen Access

Constitutive Regulation of Cardiac Fatty Acid Metabolism through Peroxisome Proliferator-activated Receptor α Associated with Age-dependent Cardiac Toxicity

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Population

PPARalpha-null mice and wild-type mice

Comparison

Genetic knockout of PPARalpha vs Wild-type mice

Design

Preclinical

Authors

KWKenichi WatanabeObihiro University of Agriculture and Veterinary Medicine HFHiroshi FujiiTohoku University TTToshihiro TakahashiCentral Research Institute of Electric Power Industry

Discussion

Member takes

Implication

Animal data link PPARα loss to cardiac energy failure and fibrosis; leaves open human therapeutic relevance.

Structured PICO

Population

PPARalpha-null mice and wild-type mice

Intervention

Genetic knockout of PPARalpha (PPARalpha-null mice)

Comparator

Wild-type mice

Outcome

Myocardial beta-oxidation of medium and long chain fatty acids (octanoic acid and palmitic acid) and expression of cardiac fatty acid-metabolizing proteinssurrogate

PPARalpha is essential for constitutive cardiac fatty acid oxidation, and its absence leads to impaired energy metabolism and age-dependent myocardial damage.

Cite This Study

Watanabe et al. (2000) studied this question.

synapsesocial.com/papers/6a178aa08d470cd99253615f https://doi.org/10.1074/jbc.m000248200

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Constitutive Regulation of Cardiac Fatty Acid Metabolism through Peroxisome Proliferator-activated Receptor α Associated with Age-dependent Cardiac Toxicity

Discussion

Member takes

Implication

Structured PICO

Cite This Study

Constitutive Regulation of Cardiac Fatty Acid Metabolism through Peroxisome Proliferator-activated Receptor α Associated with Age-dependent Cardiac Toxicity

Discussion

Member takes

Implication

Structured PICO

Cite This Study

Also Consider

Also Consider