What does this research mean for the field?

The serotonin system plays a critical role in the pathobiology of pulmonary arterial hypertension, making serotonin synthesis, transporters, and receptors promising therapeutic targets. Novelty: ClaimNovelty.SYNTHESIS. Consensus alignment: ConsensusAlignment.NEUTRAL.

June 9, 2008British Journal of PharmacologyOpen Access

Pulmonary hypertension: therapeutic targets within the serotonin system

Q: What is the clinical evidence from this study?

Study design: Review. Population: Pulmonary arterial hypertension (PAH). Intervention: Therapeutic targets within the serotonin system.

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Key result

This review discusses the serotonin hypothesis of pulmonary arterial hypertension and highlights possible therapeutic targets within the serotonin system.

Population

Patients with pulmonary arterial hypertension (PAH)

Design

Review

Authors

YDYvonne DempsieGlasgow Caledonian University MMMargaret R. MacLeanVascular / Pulmonary Vascular

Discussion

Member takes

Implication

Highlights potential serotonin targets in PAH; leaves open validation in prospective trials before any clinical adoption.

Structured PICO

Population

Patients with pulmonary arterial hypertension (PAH)

Intervention

Therapeutic targets within the serotonin system (e.g., Tph1, serotonin transporter, serotonin receptors)

This review highlights the pathobiology of serotonin in pulmonary arterial hypertension and identifies potential therapeutic targets within the serotonin system.

Cite This Study

Dempsie et al. (2008) conducted a review in Pulmonary arterial hypertension (PAH). Therapeutic targets within the serotonin system was evaluated. This review discusses the serotonin hypothesis of pulmonary arterial hypertension and highlights possible therapeutic targets within the serotonin system.

synapsesocial.com/papers/6a178abb8d470cd992536186 https://doi.org/10.1038/bjp.2008.241

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June 9, 2008British Journal of PharmacologyOpen Access

Pulmonary hypertension: therapeutic targets within the serotonin system

View Full Paper

Ask AI

Bookmark

Key result

This review discusses the serotonin hypothesis of pulmonary arterial hypertension and highlights possible therapeutic targets within the serotonin system.

Population

Patients with pulmonary arterial hypertension (PAH)

Design

Review

Authors

YDYvonne DempsieGlasgow Caledonian University MMMargaret R. MacLeanVascular / Pulmonary Vascular

Discussion

Member takes

Implication

Highlights potential serotonin targets in PAH; leaves open validation in prospective trials before any clinical adoption.

Structured PICO

Population

Patients with pulmonary arterial hypertension (PAH)

Intervention

Therapeutic targets within the serotonin system (e.g., Tph1, serotonin transporter, serotonin receptors)

This review highlights the pathobiology of serotonin in pulmonary arterial hypertension and identifies potential therapeutic targets within the serotonin system.

Cite This Study

synapsesocial.com/papers/6a178abb8d470cd992536186 https://doi.org/10.1038/bjp.2008.241

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