Key result
Delivery of the KCa3.1 blocker TRAM-34 via coated balloon catheter prevented smooth muscle phenotypic modulation and reduced postangioplasty restenosis by 38% at 14 days and 22% at 28 days.
Why the study?
Does local delivery of the KCa3.1 blocker TRAM-34 via coated balloon prevent smooth muscle phenotypic modulation and limit restenosis in a swine model of postangioplasty?
Does local delivery of the KCa3.1 blocker TRAM-34 via coated balloon prevent smooth muscle phenotypic modulation and limit restenosis in a swine model of postangioplasty?
p-value: p=<0.05
Local delivery of the KCa3.1 blocker TRAM-34 via balloon catheter prevents acute smooth muscle phenotypic modulation and reduces subsequent restenosis in a preclinical swine model.
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May limit restenosis in swine angioplasty; leaves open translation of KCa3.1 blockade to human outcomes.
Tharp et al. (2008) studied Postangioplasty restenosis (n=20). TRAM-34 coated balloon catheter vs. Noncoated balloon catheter was evaluated on Postangioplasty restenosis (normalized intimal to medial thickness ratio) (p=<0.05). Delivery of the KCa3.1 blocker TRAM-34 via coated balloon catheter prevented smooth muscle phenotypic modulation and reduced postangioplasty restenosis by 38% at 14 days and 22% at 28 days.
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