April 15, 1996Circulation
Neointimal Thickening After Severe Coronary Artery Injury Is Limited by Short-term Administration of a Factor Xa Inhibitor
Why the study?
Does short-term administration of a factor Xa inhibitor (rTAP) reduce neointimal thickening after severe coronary artery injury in a porcine model?
Population
Porcine coronary balloon angioplasty model
Comparison
Recombinant tick anticoagulant peptide… vs Placebo continuous intravenous infusion for 60…
Design
Preclinical
Follow-up
28 days
Authors
Discussion
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Member takes
Implication
Does not inform clinical use of factor Xa inhibitors to limit restenosis; leaves open thrombin's role in human neointimal formation.
Structured PICO
Does short-term administration of a factor Xa inhibitor (rTAP) reduce neointimal thickening after severe coronary artery injury in a porcine model?
P
Population
Porcine coronary balloon angioplasty model (pigs undergoing severe coronary artery injury with an oversized metallic coil)
I
Intervention
Recombinant tick anticoagulant peptide (rTAP) continuous intravenous infusion (average dose 194 micrograms/kg/min) for 60 hours, with a 6.5 mg bolus on the day of injury, targeting an activated clotting time of 200 seconds
C
Comparator
Placebo (vehicle only) continuous intravenous infusion for 60 hours
O
Outcome
Neointimal thickness at 28 days after injurysurrogate
Short-term administration of a factor Xa inhibitor significantly reduces long-term neointimal thickening after severe coronary artery injury in a porcine model, implicating thrombin generation in neointimal formation.
Cite This Study
Schwartz et al. (1996) studied this question.