Why the study?
Does prolonged thrombin inhibition with hirudin reduce neointima formation after balloon angioplasty in a porcine model?
Population
36 pigs undergoing coronary angioplasty
Comparison
Hirudin administered as bolus, short-term, or… vs Control group receiving 100 IU heparin/kg bolus
Design
Preclinical
Follow-up
4 weeks
Authors
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Prolonged thrombin inhibition may limit restenosis in animal models; leaves open translation to human PCI outcomes.
Does prolonged thrombin inhibition with hirudin reduce neointima formation after balloon angioplasty in a porcine model?
Prolonged thrombin inhibition for 14 days significantly reduces neointima formation after balloon angioplasty in a porcine model, suggesting sustained therapy may be needed to prevent restenosis.
Gallo et al. (1998) studied this question.
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