Why the study?
Does local delivery of r-hirudin reduce platelet deposition and mural thrombus formation compared to systemic treatment alone following balloon angioplasty in a pig model?
Population
29 pigs undergoing balloon angioplasty of the carotid arteries
Comparison
Local delivery of r-hirudin via a percutaneous… vs Systemic treatment alone with local placebo…
Design
Preclinical
Follow-up
1 hour
Authors
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Local r-hirudin delivery may limit post-angioplasty thrombosis in porcine models; hypothesis-generating, does not yet inform practice.
Does local delivery of r-hirudin reduce platelet deposition and mural thrombus formation compared to systemic treatment alone following balloon angioplasty in a pig model?
Local delivery of r-hirudin via a perfusion catheter significantly reduces short-term platelet deposition and mural thrombus formation after angioplasty compared to systemic treatment alone in a pig model.
Meyer et al. (1994) studied this question.
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