Why the study?
Does hirulog-1 reduce neointima formation and PDGF expression in balloon-injured rat carotid arteries?
Population
Rat carotid arteries injured by balloon catheter
Comparison
Hirulog-1 vs Saline alone; heparin for safety and aPTT…
Design
Preclinical
Authors
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Supports preclinical testing of hirulog-1 in vascular injury; leaves open translation to human restenosis prevention.
Does hirulog-1 reduce neointima formation and PDGF expression in balloon-injured rat carotid arteries?
In a rat model of balloon catheter injury, multiple infusions of the thrombin inhibitor hirulog-1 reduced neointima formation and PDGF expression without the severe bleeding complications seen with heparin.
Xue et al. (2000) studied this question.
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