Key result
Recombinant hirudin diminished tissue factor expression 28 days after balloon angioplasty compared with heparin controls in 87 rabbit and porcine models.
Why the study?
Does recombinant hirudin reduce tissue factor expression after balloon angioplasty in rabbit and porcine models?
Population
32 cholesterol-fed New Zealand White rabbits and 55 Yorkshire-Albino swine undergoing balloon angioplasty
Comparison
Recombinant hirudin vs Bolus heparin only
Design
Preclinical
Follow-up
28 days
Authors
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Supports hirudin for reduced neointimal thrombogenicity in animal angioplasty models; hypothesis-generating for clinical PCI outcomes.
Does recombinant hirudin reduce tissue factor expression after balloon angioplasty in rabbit and porcine models?
Specific thrombin inhibition with hirudin attenuates tissue factor expression in the neointima 1 month after balloon angioplasty in animal models, suggesting a potential mechanism for prolonged reduction in thrombogenicity.
Gertz et al. (1998) studied Balloon angioplasty injury (n=87). Recombinant hirudin (r-hirudin) vs. Bolus heparin only was evaluated on Tissue factor (TF) distribution and expression. Recombinant hirudin diminished tissue factor expression 28 days after balloon angioplasty compared with heparin controls in 87 rabbit and porcine models.
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