January 1, 1994Cardiovascular Research

Maintenance of canine coronary artery patency following thrombolysis with front loaded plus low dose maintenance conjunctive therapy. A comparison of factor Xa versus thrombin inhibition

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Why the study?

Does rTAP compared to rHIR improve reperfusion and maintain vessel patency in a canine model of coronary artery thrombosis treated with rt-PA?

Population

Anaesthetised dogs with occlusive coronary artery thrombosis induced by electrical injury of the intimal…

Comparison

Recombinant tick anticoagulant peptide given as… vs Recombinant hirudin given as high dose front…

Design

Preclinical

Follow-up

180 min after rt-PA termination

Authors

JLJ J LynchCommonwealth Scientific and Industrial Research Organisation GSGR SitkoMerck & Co., Inc., Rahway, NJ, USA (United States)MMMichael J. MellottMerck & Co., Inc., Rahway, NJ, USA (United States)

Discussion

Member takes

Implication

rTAP may outperform direct thrombin inhibition for post-thrombolytic patency in canines; leaves open translation to human coronary thrombosis.

Structured PICO

Does rTAP compared to rHIR improve reperfusion and maintain vessel patency in a canine model of coronary artery thrombosis treated with rt-PA?

Population

Anaesthetised dogs with occlusive coronary artery thrombosis induced by electrical injury of the intimal surface of the left circumflex coronary artery (n=25)

Intervention

Recombinant tick anticoagulant peptide (rTAP) given as high dose front loading infusion (200 micrograms/kg/min for 45 min) plus low dose maintenance infusion (10 or 20 micrograms/kg/min for 180 min), in combination with a 90 min infusion of rt-PA

Comparator

Recombinant hirudin (rHIR) given as high dose front loading infusion (300 micrograms/kg/min for 45 min) plus low dose maintenance infusion (20 micrograms/kg/min for 180 min), in combination with a 90 min infusion of rt-PA

Outcome

Reperfusion rate and maintenance of vessel patency during the 180 min period following rt-PA terminationsurrogate

In a canine model of coronary thrombosis, the factor Xa inhibitor rTAP was more effective than the direct thrombin inhibitor rHIR at maintaining post-thrombolysis vessel patency when used as conjunctive therapy with rt-PA.

Cite This Study

Lynch et al. (1994) studied this question.

synapsesocial.com/papers/6a90e342d2f2d69b3a744b5a https://doi.org/10.1093/cvr/28.1.78

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Implication

rTAP may outperform direct thrombin inhibition for post-thrombolytic patency in canines; leaves open translation to human coronary thrombosis.

Maintenance of canine coronary artery patency following thrombolysis with front loaded plus low dose maintenance conjunctive therapy. A comparison of factor Xa versus thrombin inhibition

Discussion

Member takes

Implication

Structured PICO

Cite This Study

Maintenance of canine coronary artery patency following thrombolysis with front loaded plus low dose maintenance conjunctive therapy. A comparison of factor Xa versus thrombin inhibition

Discussion

Member takes

Implication

Structured PICO

Cite This Study

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Also Consider