January 1, 1997Thrombosis and Haemostasis

Transient Interruption of Arterial Thrombosis by Inhibition of Factor Xa Results in Long-term Antithrombotic Effects in Baboons

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Population

Baboon model of arterial thrombosis

Comparison

Recombinant tick anticoagulant peptide… vs Control studies

Design

Preclinical

Follow-up

55 hours

Authors

HKH F KotzéUniversity of the Free State SLS LamprechtUniversity of the Free State PBP N BadenhorstUniversity of the Free State

Discussion

Member takes

Implication

Should not change clinical practice; hypothesis-generating for r-TAP in arterial thrombosis and requires human trials.

Structured PICO

Population

Baboon model of arterial thrombosis (Dacron vascular graft segments inserted as extensions into permanent femoral arteriovenous shunts)

Intervention

Recombinant tick anticoagulant peptide (r-TAP) administered intravenously at 10 micrograms/kg/min (low dose) or 25 micrograms/kg/min (high dose) for two hours

Comparator

Control studies

Outcome

Total platelet deposition over 55 hours (calculated as the area under the deposition curve)surrogate

A 2-hour treatment with a full antithrombotic dose of r-TAP markedly reduced both the rate of platelet deposition after treatment was stopped and the total number of platelets deposited over 55 hours in a baboon model of arterial thrombosis.

Cite This Study

Kotzé et al. (1997) studied this question.

synapsesocial.com/papers/6a7e037530df0be8fb5ca359 https://doi.org/10.1055/s-0038-1656126

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Transient Interruption of Arterial Thrombosis by Inhibition of Factor Xa Results in Long-term Antithrombotic Effects in Baboons

Discussion

Member takes

Implication

Structured PICO

Cite This Study

Transient Interruption of Arterial Thrombosis by Inhibition of Factor Xa Results in Long-term Antithrombotic Effects in Baboons

Discussion

Member takes

Implication

Structured PICO

Cite This Study

Also Consider

Also Consider