Key result
Enterovirus 71 inhibits the cellular type I interferon antiviral pathway by downregulating JAK1 protein expression at a post-transcriptional level.
EV71 evades the host immune response by downregulating JAK1 protein expression, thereby inhibiting cellular type I interferon signaling.
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Animal data on EV71 JAK1 downregulation warrant caution extrapolating to humans; human studies needed to assess relevance.
Liu et al. (2014) studied Enterovirus 71 (EV71) infection. Enterovirus 71 (EV71) infection vs. Uninfected cells was evaluated on Cellular type I IFN response (STAT1/STAT2 phosphorylation and JAK1 expression). Enterovirus 71 inhibits the cellular type I interferon antiviral pathway by downregulating JAK1 protein expression at a post-transcriptional level.
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