Why the study?
Do responses to platelet agonists and antagonists differ between classical light transmission aggregometry and 96-well plate aggregometry?
Comparison
96-well plate aggregometry vs Classical light transmission aggregometry (LTA)
Design
Review
Key result
96-well plate aggregometry and classical light transmission aggregometry yield different responses to platelet agonists and antagonists, demonstrating that the assays are not interchangeable.
Authors
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Assay-specific interpretation is required for platelet testing; leaves open standardization needs for consistent clinical and research use.
Do responses to platelet agonists and antagonists differ between classical light transmission aggregometry and 96-well plate aggregometry?
Classical light transmission aggregometry and 96-well plate aggregometry are not interchangeable and yield qualitatively different responses to platelet agonists and antagonists.
Chan et al. (2018) conducted a review in Platelet function testing. 96-well plate aggregometry vs. Classical light transmission aggregometry (LTA) was evaluated on Platelet aggregation responses to agonists and antagonists. 96-well plate aggregometry and classical light transmission aggregometry yield different responses to platelet agonists and antagonists, demonstrating that the assays are not interchangeable.
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